Bioassay of heptachlor for possible carcinogenicity
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Bioassay of heptachlor for possible carcinogenicity

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Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Program, Carcinogen Bioassay and Program Resources Branch in Bethesda, Md .
Written in English

Subjects:

  • Pesticides -- Toxicology.,
  • Carcinogens.,
  • Heptachlor.

Book details:

Edition Notes

Statement[prepared at Tracor Jitco, inc.].
SeriesDHEW publication ; no. (NIH) 77-809, Carcinogenesis technical report series ; no. 9, National Cancer Institute carcinogenesis technical report series -- no. 9., DHEW publication -- no. (NIH) 77-809.
ContributionsTracor Jitco, Inc.
The Physical Object
Paginationxi, 111 p. :
Number of Pages111
ID Numbers
Open LibraryOL17516888M

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On day 2, contamination with lindane, aldrin, heptachlor epoxide and heptachlor averaged , , and ng/g fat, respectively, and the levels showed a linear decrease on subsequent days.   HEPTACHLOR First draft prepared by Dr. W. Phang, US Environmental Protection Agency, Washington, D.C., United States EXPLANATION The JMPR evaluated heptachlor in (Annex I, 14) and concluded that an adequate carcinogenicity study in a second species of animal other than the rat was needed. An estimated ADI of mg/kg/bw was allocated. Heptachlor (1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene) is an insecticide that was used on corn, alfalfa, hay, and vegetables, and as a termiticide. During the mids, use of heptachlor on food crops was phased out due to the persistence of the chemical and its epoxide. S.E. Koshlukova, N.R. Reed, in Encyclopedia of Toxicology (Third Edition), Carcinogenicity. Rodent dietary inclusion bioassays with chlordane and mixtures with heptachlor and heptachlor epoxide showed increased liver neoplasm in multiple strains of mice (adenoma, carcinoma, and hemangioma) and rats (adenoma), and thyroid follicular–cell adenomas and carcinomas in rats.

A bioassay of p,p'-ethyl-DDD for possible carcinogenicity was conducted by administering the test chemical in feed to F rats and B6C3F1 mice. Groups of 50 rats of each sex were administered p,p'-ethyl-DDD at one of two doses, either 3, or 7, ppm, for weeks. Matched controls consisted of . Heptachlor is a constituent of technical grade chlordane, approximately 10 percent by weight. Heptachlor was used from to as a soil and seed treatment to protect corn, small grains, and sorghum from pests. It was also used to control ants, cutworms, maggots, termites, and .   A bioassay of hexachlorophene for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer rats. Groups of 24 rats of each sex were administered hexachlorophene at one of three doses, eit 50, or ppm, for weeks. Higher doses of ppm, used in 8-week subchronic. NCI (National Cancer Institute). Bioassay of Chlordane for possible carcinogenicity. NCI Carcinogenesis Tech Rep Ser No. 8. Also Publ as DHEW Publ No. (NIH) U.S. EPA. Updated health effects assessment for Chlordane.

McGregor, D., Brown, A., Cattanach, P., Edwards, I., McBride, D., Riach, C., and Caspary, W. Responses of the LY tk+/tk- mouse lymphoma cell forward mutation. Bioassay of sulfisoxazole for possible carcinogenicity. Bibliographic Details; Corporate Authors: National Cancer Institute (U.S.). If your book is not available on E-ZBorrow, you can request it through ILLiad (ebooks unavailable). a Bioassay of sulfisoxazole for possible carcinogenicity. Book Govt Pub, Federal: Additional Physical Format: Online version: Bioassay of endosulfan for possible carcinogenicity (OCoLC) Material Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.). A bioassay of technical-grade piperonyl butoxide for possible carcinogenicity was conducted by administering the test chemical in feed to Fischer rats and B6C3F1 mice. Groups of 50 rats of each sex were administered piperonyl butoxide in the diet at.